Home Brain & Cognition Can L-Methylfolate Plus Vitamin B12 Benefit Your Mood, Heart, and Brain Health?
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Can L-Methylfolate Plus Vitamin B12 Benefit Your Mood, Heart, and Brain Health?

Feeling down and just not quite yourself? Or are you planning to get pregnant or pregnant already? You might be missing a key ingredient. L-Methylfolate or L-Meth is the biologically active form of Folate (Vitamin B9), ready to be absorbed directly into your bloodstream. A special formulation offers a potent dose of 15 mg L-Meth to optimize folate levels. Plus, with the addition of Methyl-B12, a vital cofactor, you’re in for a health-boosting experience.

The Synergy of L-Methylfolate and Methyl-B12

B vitamins are essential nutrients your body needs to function correctly. They are usually made by plants and are found in foods. It includes fruits, vegetables, meat, dairy, and eggs. However, vitamin B12 is made by bacteria and is mostly found in animal-based foods. When you eat these foods, your body can use the B vitamins directly. Additionally, your body can change them into a form it can use.

Folic acid (synthetic) vs. L-methylfolate (active form) 

  • L-meth is better at energy production and reduced homocysteine (Hcy) levels for heart health.
  • L-meth results in improved mood, especially for depression resistant to SSRIs.

Vitamin B12:

  • Helps form red blood cells and transport oxygen.
  • Potentially increases energy levels and mental clarity (potentially dependent on existing B12 deficiency or brain issues)


  • L-methylfolate offers various benefits beyond basic folate functions.
  • Vitamin B12 benefits may depend on pre-existing deficiencies or conditions.
  • Both are a powerful tandem for enhancing overall health and well-being.

L-Methylfolate For People With Gene Variations

The MTHFR gene is like a recipe for an enzyme that helps your body use folate, important for making DNA and modifying proteins. This gene can sometimes have variations, or mutations, which might make it harder for some people to process folate properly.

Researchers explored different versions of a gene called MTHFR (677C>T and 1298A>C), linked to folate, in various populations:

  • African descent: The least variation in two specific gene versions: 16% for 677C>T and 17% for 1298A>C
  • European descent (Caucasians): Some variation: 32% for 677C>T and 32% for 1298A>C
  • Hispanic descent: The most variation: 42% for 677C>T and 22% for 1298A>C

Despite some differences, overall, people from different backgrounds are genetically quite similar. Certain supplements contain a special form of folate that may be more suitable for people with this specific genetic variation. This form is L-Methylfolate. Experts suggest it could be as effective or even potentially better than the usual folic acid found in many foods and supplements.

The Multi-Faceted Potential Benefits of L-Methylfolate with Methyl-B12

L-Methylfolate (15 mg) Plus Methyl-B12 is a supplement designed to support brain and heart health and balance energy, hormones, and mood. It’s a form of Vitamin B9 that’s ready to be used by the body, helping with neurotransmitter production. This liquid supplement also includes Methyl-B12 to enhance its benefits. It’s suitable for boosting overall health and well-being.

Alleviate Mood 

Folic acid, and L-meth are crucial for making brain chemicals. These include serotonin, melatonin, dopamine, and a couple of others that help your mood. For people whose mood problems don’t get better with usual meds, taking supplements can help. These can balance out nutrients and help with brain signals. 

Experts suggest L-meth can be used alongside regular antidepressants to help people who haven’t found relief with other meds. Moreover, studies show that adding L-meth to regular antidepressants can help, especially in people who are overweight or have inflammation.

Support Brain Health

Research shows that vitamin B12 is crucial for brain health at all ages. Getting enough B12 during pregnancy can lead to better brain skills in children later. Good B12 levels are linked to better social and thinking skills in young kids. Teenagers who don’t get enough B12, like those on vegan diets, can have weaker brain performance. Moreover, higher B12 intake is tied to better brain function in midlife for adults. Older adults with low B12 might have a higher risk of memory problems and depression. This highlights B12’s role in brain health and development.

Boost Heart Health

High levels of Hcy in the blood might increase the risk of heart and blood vessel diseases. People with lower folate (folic acid), vitamin B12, and vitamin B6 have higher Hcy. A review of 12 studies reveals taking folic acid can lower Hcy levels by about 25%. 

Similarly, taking folic acid and vitamin B12 can help improve blood vessel function in people with heart disease. This improvement seems to happen because these vitamins lower Hcy levels. When Hcy is lower, the blood vessels work better. This is important because better blood vessel function can reduce the risk of heart problems. 

Help Women In Childbearing Age

Folic acid is especially crucial as it prevents health issues in both a mom-to-be and her unborn baby. L-methylfolate is good because some people’s bodies can use it better. Many people have a gene thing that makes it hard to turn regular folic acid into the form the body can use. So, L-meth could be a better choice, especially for women who have had certain health problems in their families.

Additionally, it helps increase folate in the body and decrease Hcy, which is linked to some pregnancy risks. A study even found that women who took prenatal vitamins with L-meth had higher iron levels, which means less chance of anemia. 

Prevent Birth Problems

Taking folic acid before and during pregnancy is super important to prevent certain birth defects in babies. A recent study shows that L-methylfolate might be even better at increasing its levels in the body. Taking folic acid when you’re planning to get pregnant can do more than just prevent birth defects in a baby’s brain and spine. 

Experts think folic acid might work by managing Hcy levels. Since folic acid helps the placenta to develop in early pregnancy, not having enough might cause these issues.  It includes high blood pressure in pregnancy, early separation of the placenta, and babies not growing enough. 

Key Takeaway

B vitamins are essential for health, with B12 found in animal foods aiding red blood cell production and energy levels. Folic acid, a synthetic B9 found in certain foods and supplements, and its active form, L-methylfolate, are important for mood and brain health. They help create mood-regulating chemicals and can boost the effectiveness of antidepressants, especially in people with depression linked to being overweight or having inflammation. Additionally, they are important during pregnancy to prevent birth defects and support the baby’s growth.

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